The enigma of the lower gut‐associated lymphoid tissue (GALT)
[摘要] ArtiodactylspossessGALTthatappearsinfetallifeandislocatedattheextremeendoftheileum.TheseIPPcontainmostlyBcellsandinvoluteearlyinpostnatallife.Rabbitshaveasimilarlylocatedlymphoidorgan,calledthesacculusrotundus.StudiesinsheepandrabbitshaveledtotheconceptthatthelowerhindgutGALTrepresentsprimarylymphoidtissueforBcellsandisnecessaryfornormalBcelldevelopment,analogoustothebursaofFabricius.ThisreviewtracesthehistoryoftheobservationsandtheoriesthathaveledtotheexistingconceptconcerningtheroleoflowerGALT.WethenreviewrecentdatafrompigletswithresectedIPPthatchallengestheconceptthattheIPPisprimaryBcelllymphoidtissueandthatartiodactylsandrabbitsaremembersoftheGALTgroupinthesamecontextasgallinaceousbirds.EliminatingtheIPPastheprimarylymphoidtissueforBcellsleadstothehypothesisthattheIPPactsasfirst‐respondermucosallymphoidtissue...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] B lymphocytes;lymphogenesis;B cell development;mucosal immunity;Peyerˈs patches [时效性]
