The neutrophil in antineutrophil cytoplasmic autoantibody‐associated vasculitis
[摘要] Necrotizing,small‐vesselvasculitisdevelopsinpatientswithcirculatingANCAs.NeutrophilsandmonocytesharborthetwomajorANCAantigens,PR3andMPO.AwholebodyofinvitroexperimentsimplicatedANCA‐activatedneutrophileffectorfunctionsinthepathogenesisofvasculitis,whereastheroleofmonocytesislesswell‐characterized.Mousemodelsforanti‐MPO‐inducedvasculitisweredevelopedtostudyANCA–neutrophilinteractionsincomplexinvivosituations.WenotonlydiscussthesignificanceofANCA–neutrophilinteractionsfordiseaseinductionbutalsohowadetailedunderstandingoftheseinteractionshelpstoidentifynoveltreatmenttargetsforANCAvasculitis...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] inflammation;ANCA;animal model;crescentic glomerulonephritis [时效性]
