At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies
[摘要] Theidentificationofananti‐tumoreffectdisplayedbycellsofinnateimmunityhasopenednewscenarios,notonlyinthefieldofallo‐HSCTbutalsofornontransplantedpatientswithhematologicalmalignanciesorsolidtumors.Donor‐derivedNKcellshavebeenshowntocontributetotheeradicationofmalignantcellsafterallo‐HSCT,whenrecipientslackligandsfortheirinhibitoryreceptors.ThesealloreactivedonorNKcellscanalsokillrecipientAPCsandCTLs,thuspreventingtheoccurrenceofGvHDandgraftrejection.TheroleofactivatingreceptorsonthecapacityofNKcellstokillleukemiatargetshasbecomeevidentinthelastyears.Theadoptiveinfusionofexvivo‐activatedNKcellshasbeeninvestigatedrecentlyinPhaseI/IItrialsonpatientswithhematologicalmalignanciesandsolidtumors,withpromisingresults.γδTlymphocytesarealsoabletodisplayanti‐tumoractivity—thisprovidingthebiologicalrationaleforPhaseI/IItrialsinlymphoproliferativedisordersandsolidtumors.AminobisphosphonatesareclinicallyavailablecompoundsabletoboostγδTcellfunction.AsγδTcellsdonotcauseGvHD,theycouldalsobetransducedwithtumor‐associatedchimericantigenreceptorsandsafelyinfusedinallo‐HSCTrecipients.Basicaspectsofinnateimmunityrelevanttothefieldwillbecoveredbyacompanionreviewarticle...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] NK cells;Haploidentical hematopoietic stem cell transplantation;γ‐δT cells;graft‐versus‐host disease;graft‐versus‐leukemia effect [时效性]
