Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis

[摘要] Introduction and ObjectivesParaoxonases may exert anti-atherogenic action by reducing lipid peroxidation. Previous studies examined associations between polymorphisms in the paraoxonase 1 (PON1) gene and development of coronary artery disease (CAD), with inconsistent results. Given the similarities in clinical and pathophysiological risk factors of CAD and calcific aortic valve stenosis (CAVS), we postulated a link between PON1 alleles and CAVS progression.

[学科分类] 心脏病和心血管学

[关键词] Calcific aortic stenosis;polymorphism;paraoxonase;atherosclerosis;genetics;association