and Antioxidant Activity of Endophytic Fungi from Mahogoni Plant (Swietenia macrophylla King

[摘要] Diabetes mellitus is a degenerative disease characterized by hyperglycemia due to insulin insulin deficiency either absoluteor relative. This study was conducted to isolate endophytic fungi from plant twigs mahogany ( Swietenia macrophyllaKing) which active as antidiabetic and antioxidant. Antidiabetic activity conducted by using the α-glucosidase inhibitory and antioxidant activity using free radical reduction method with reagent 2.2-diphenyl-1-picrylhydrazyl (DPPH). Isolation of microbes conducted in the media Corn Meal Malt Agar (CMMA) and Potato Dextrose Agar (PDA) which 7 isolates of fungus in total. Inhibitory activity against α-glucosidase to extract the filtrate and biomass of the isolates A.Sm.2F (72.59 and 92.22%), A.Sm.3F (81.87 and 79.37%), B.Sm.1F (63.40 and 98.84%), B.Sm.2F (65.60 and 62.72%), B.Sm.3F (93.91 and 51.48%), B.Sm.4F (87.48 and 74.64%) thus has potential as an antidiabetic activity. B.Sm.1F was the only isolates active as antioxidants with IC 50of 84.41.

[学科分类] 化学工程（综合）

[关键词] antidiabetic;antioxidant;Swietenia macrophylla King;α-glucosidase;2.2-diphenyl-1-picrylhydrazyl