Attenuation of motor deficits by hydroethanolic extract of Poincianella pyramidalis in a Parkinsonxe2x80x99s disease model

[摘要] The present study aimed to evaluate the possible neuroprotective effect of the hydroethanolic extract of Poincianella pyramidalis (EHPp) (Tul.) L. P. Queiroz (Fabaceae), an endemic plant found in Northeastern Brazil, commonly used in folk medicine, on the motor deficits induced by repeated treatment with reserpine (RES) in rats. Adult male Wistar rats received 10 s.c. injections of 0.1 mg/kg RES or vehicle (VR), every 48 h, and daily i.p. injections daily of HEPp (25 mg/kg) or vehicle (VE). Throughout treatment, catalepsy behavior and oral movements were scored. After behavioral tests, superoxide dismutase (SOD) and catalase (CAT) activities were evaluated in the prefrontal cortex, hippocampus and striatum. RES treatment induced a progressive increase of catalepsy time in the treated group compared to control groups starting at day 15. RES also increased the number of vacuous chewing movements, tongue protrusions and duration of facial twitching. Treatment with HEPp attenuated the motor deficit in the catalepsy test and delayed the onset of oral movements induced by RES. No significant changes were observed in the antioxidant assay. Taken together, these results show a beneficial effect of HEPp on motor deficits induced by reserpine, suggesting a neuroprotective effect in a rat model of PD.

[学科分类] 植物学

[关键词] El presente estudio tuvo como objetivo evaluar el posible efecto neuroprotector del extracto hidroalcohoxccx81lico de Poincianella pyramidalis (EHPp) (Tul.) L. P. Queiroz (Fabaceae);en los dexccx81ficits motores inducidos por el tratamiento repetido con reserpina (RES) en ratas. Ratas Wistar machos adultos recibieron 10 inyecciones (s.c.) de 0;1 mg/kg de RES o vehixccx81culo (VR) a cada 48 h;y inyecciones (i.p.) diarias de EHPp (25 mg/kg) o vehixccx81culo (VE). Durante todo el tratamiento se observoxccx81 el comportamiento de la catalepsia y movimientos orales. Despuexccx81s de anaxccx81lisis de comportamientos;fueron evaluados el superoxccx81xido dismutasa (SOD) y las actividades de catalasa (CAT) en la corteza prefrontal;el hipocampo y el cuerpo estriado. El tratamiento con EHPp atenuoxccx81 el dexccx81ficit motor en el ensayo de catalepsia y el retraso en el comienzo de los movimientos orales inducidos por RES. No se observaron cambios significativos en el ensayo antioxidante. Estos resultados muestran un efecto beneficioso de EHPp en dexccx81ficits motores inducidos por RES;sugiriendo un efecto neuroprotector en un modelo de enfermedad de Parkinson.