Isolation and Complete Genome Sequencing of Zika Virus Imported from the Dominican Republic to Japan

[摘要] Zika virus (ZIKV) infection has been documented within Central and South America, Asia, and Africa. Here we report the isolation of virus from a patient infected with ZIKV returning to Japan from the Dominican Republic. The ZIKV strain was imaged by electron microscopy and its complete genome sequence was analyzed. Phylogenetic analysis and molecular characterization revealed that the strain was of Asian lineage, and carried 2 unique mutations in its NS5 region. These mutations are characteristic of strains that originated in the Dominican Republic and the USA in 2016.

[学科分类] 传染病学

[关键词] Zika virus;electron microscopy;complete genome sequence;Japan