Serum amyloid P: a systemic regulator of the innate immune response
[摘要] ThepentraxinSAPreducesneutrophiladhesiontoECMproteins,inhibitsthedifferentiationofmonocytesintofibrocytes,attenuatesprofibroticmacrophages,activatesthecomplementpathway,andpromotesphagocytosisofcelldebris.Together,theseeffectsofSAPregulatekeyaspectsofinflammationandsetathresholdforimmunecellactivation.Here,wepresentareviewofSAPbiologywithanemphasisonSAPreceptorinteractionsandhowtheeffectofSAPonmonocytesandmacrophageshasbeenexploredtodevelopthisproteinasatherapeuticforrenalandlunginjuries.WealsodiscusshowthereremainmanyunansweredquestionsabouttheroleofSAPininnateimmunity...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] neutrophil adhesion;macrophage polarization;fibrocyte differentiation;Fcγreceptors;phagocytosis;fibrosis [时效性]
