Innate immune cell networking in hepatitis C virus infection
[摘要] Persistentviralinfection,suchasHCVinfection,istheresultoftheinabilityofthehostimmunesystemtomountasuccessfulantiviralresponse,aswellastheescapestrategiesdevisedbythevirus.Althougheachindividualcomponentofthehostimmunesystemplaysimportantrolesinantiviralimmunity,theinteractivenetworkofimmunecellsasawholeactsagainstthevirus.Theinnateimmunesystemformsthefirstlineofhostdefenseagainstviralinfection,andthus,viruseliminationorchronicHCVinfectionislinkedtothedirectoutcomeoftheinteractionsbetweenthevariousinnateimmunecellsandHCV.ByunderstandinghowthedistinctcomponentsoftheinnateimmunesystemfunctionbothindividuallyandcollectivelyduringHCVinfection,potentialtherapeutictargetscanbeidentifiedtoovercomeimmunedysfunctionandcontrolchronicviralinfection...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] chronic;NK cells;dendritic cells;monocytes;macrophages;sensors [时效性]
