IFN‐λ is able to augment TLR‐mediated activation and subsequent function of primary human B cells
[摘要] Duringthepastdecade,increasedemphasishasbeenplacedonfindingalternativestoIFN‐α‐basedtherapies.Onesuchalternative,IFN‐λ,hasshowntherapeuticpromiseinavarietyofdiseases,butresearchofthisfamilyofcytokineshasbeenprimarilyfocusedontheirantiviralactivities.ThegoalofthepresentstudywastoinvestigatetheroleofIFN‐λintheregulationandmodulationofBcellfunction.Weshowthat,similartoIFN‐α,IFN‐λ1isabletoaugmentTLR‐mediatedBcellactivation,partiallyattributedtoanupregulationofTLR7expression,andthatbothnaϊveandmemoryBcellsexpressthelimitingtypeIIIIFNreceptorcomponent,IFN‐λR1.Furthermore,thisIFN‐λ‐enhancedBcellactivationresultedinincreasedcytokineandIgproductionduringTLR7challenge,mostprominentlyaftertheadditionofhelperTcellsignals.Ultimately,theseelevatedcytokineandIglevelscouldbepartiallyattributedtotheincreaseinproliferationofTLR7‐challengedBcellsbybothtypeIandtypeIIIIFNs.ThesefindingsdemonstratetheabilityofIFN‐λtoboosthumoralimmunity,animportantattributetoconsiderforfurtherstudiesonimmunitytopathogens,vaccinedevelopment,andongoingadvancementoftherapeuticstrategiesaimedatreplacingIFN‐α‐basedtreatmentswithIFN‐λ...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] interferon;immunoglobulins;IL‐29;innate immunity [时效性]
