AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease
[摘要] CD5L,asolubleproteinbelongingtotheSRCRsuperfamily,isexpressedmostlybymacrophagesinlymphoidandinflamedtissues.TheexpressionofthisproteinistranscriptionallycontrolledbyLXRs,membersofthenuclearreceptorfamilythatplaymajorrolesinlipidhomeostasis.ResearchundertakenoverthelastdecadehasuncoveredcriticalrolesofCD5LasaPRRofbacterialandfungalcomponentsandinthecontrolofkeymechanismsininflammatoryresponses,withinvolvementinprocesses,suchasinfection,atherosclerosis,andcancer.Inthisreview,wesummarizethecurrentknowledgeofCD5L,itsrolesattheintersectionbetweenlipidhomeostasisandimmuneresponse,anditspotentialuseasadiagnosticbiomarkerinavarietyofdiseases,suchasTBandlivercirrhosis...
[发布日期] [发布机构]
[效力级别] [学科分类] 生理学
[关键词] Spαmacrophage;metabolic disease;SRCR domain;cancer [时效性]
