Event-Related Potentials in Sleep-Related Breathing Disorders and Insomnia

[摘要] Background: Since sleep may affect information processing and therefore event related potentials, an increased P300 latency and reduced amplitude are expected to be present when sleep is disrupted and shortened. Objective: To assess event related potentials (ERPs) in patients with sleep related breathing disorders (SRBDs) and insomnia, and the association between the severity of subjective and objective sleep alterations and the changes in ERPs. Methods: Thirty patients with SRBDs and insomnia were subjected to polysomnography (PSG), visual and auditory ERPs testing twice; pre and post sleep. Results: We found significant decrease in ERPs latencies, and increase in their amplitudes in the morning in the control group, but not in patients. Evening ERPs were not significantly different among the groups. Morning ERPs in sleep related breathing disorders had longer latencies and smaller amplitudes. Evening to morning comparison revealed the subtle ERPs abnormalities in insomnia. No significant correlation was found between the changes of ERPs in patients and their Epworth sleepiness scale scores and the PSG data. Conclusion: Normal uninterrupted sleep greatly enhances ERPs. Multiple P300 measurements especially in the morning provide more sensitive marker for assessment of sleep effects on attention processes. The difference between evening and morning ERPs is a very sensitive parameter and can detect subtle abnormalities especially in insomnia patients. Neither subjective nor objective estimates of sleep continuity can strongly explain the changes in ERPs. [Egypt J Neurol Psychiat Neurosurg.  2011; 48(2): 129-137]

[学科分类] 精神健康和精神病学